In this line, we checked the changes in DNA methylation pattern of ADH1A and ALDH2 genes between HCC tumor and adjacent normal liver tissues in patients from GEO datasets GSE37988, GSE44909, and GSE57956 but found no significant differences (Figure 4J) suggesting that ADH1A and ALDH2 expression is not regulated through DNA methylation during HCC onset and progression. This evidence concerns the gene ALDH2 and neoplasm.