In contrast, no study showed down-regulated expression of RRM1 (0 of 19) or RRM2 (0 of 19) in all subtypes of lung cancer, 22.2% (2 in 9) of the Oncomine studies demonstrated a down-regulated RRM2B expression in cases of LUSC and LCLC. The gene discussed is RRM2; the disease is lung carcinoma.