RRM2 and neoplasm: To validate the potential implication of RRM1, RRM2, and RRM2B expression in pathology and prognosis of NSCLC, 211 surgically excised tumor specimens were independently collected from the patients with LUSC and LUAD (n = 97 and 114, respectively) from three academic hospitals affiliated to Zhejiang University in China (named the ZJUC cohort hereafter).