Nuclear factor kappa-B (NF-κB) is a part of an important inflammatory signaling pathway.26 In mammalian cells, the NF-кB family has five members, including RelA (p65), RelB, c-Rel, p50/p105 (NF-кB1), and p52/p100 (NF-кB2).46,47 According to a study by Zhu et al. in 2019, adiponectin can mitigate obesity-related asthma, improve AMPK activity, and decrease iNOS, Bcl-2, and NF-κB p65 levels within the respiratory system. This evidence concerns the gene NOS2 and obesity due to melanocortin 4 receptor deficiency.