TNF and allergic asthma: In addition, eosinophils respond to these cytokines by decreasing the expression of CD68, iNOS, TNF-α, IL-6, and IL-12 and increasing CD163, Arg-1, TGF-β, IL-10, and IL-13.227,228 Therefore, attention should be dedicated to eosinophils as important contributors to the pathogenesis of allergic asthma.