In addition, adiponectin promotes inflammatory cell apoptosis by suppressing NF-κB- and tumor necrosis factor (TNF)-α-induced expression of anti-apoptotic Bcl-2 (which contains NF-κB-binding sites in its promoter region), as well as inhibiting p50 DNA binding and p65 transactivation subunits.49–51 Adiponectin can further relieve inflammation by decreasing TNF-α production through blocking TNF-α-induced iκB-α phosphorylation and subsequent NF-κB activation.52–56 Overall, adiponectin has a main role in the control of inflammation and antioxidant processes, especially in obesity-related asthma. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.