Accordingly, the inhibition of the PI3K/AKT signaling pathway reduced lung inflammation by decreasing the expression of IL-4, IL-6, IL-8, TNF-α, and IgE.117 Overall, miRNAs can have therapeutic applications in preventing airway inflammation by modulating FOXC1 and other signaling molecules, such as PI3K, AKT, NF-κB, cyclin D1, and TGF-β1. This evidence concerns the gene AKT1 and inflammation.