CYBB and cancer: The NADPH oxidase (NOX) family of proteins is one of the main producers of ROS in several cancers and ischemic stroke.55 NOXs are membrane-bound proteins with a C-terminal NADPH/FAD-binding domain and N-terminal transmembrane tandem heme groups.56 It is reported that NOX2 (gp91phox) and its homologs (Nox1, 3, 4, and 5 and Duox1/2) require p22 phox as a cosubunit and catalyze superoxide (O2−) generation via a NADPH-dependent pathway, which is subsequently converted to H2O2.