IL22 and infection: These phenotypes can be reversed via exogenous IL-22 administration, indicating the immunosuppressive effect of IL-22 on intestinal inflammation.328 In summary, these results indicate that the significance of ILC3s and derived IL-22 in protecting against pathogen infection, relieving inflammation, and facilitating symbiosis with commensals could depend on crosstalk among the gut microbiome, additional immune cells, IECs, and, surprisingly, with neuro-glial cells to maintain gut homeostasis.