The ORs for rs2391191 in Caucasian populations (for BD: 0.966; for MDD: 0.949; for major mood disorders: 0.952) are comparable with those of other risk genes for major mood disorders reported in previous large-scale meta-analyses.6 Moreover, the functional assay demonstrated that rs2391191 can influence transcription factor TCF4-binding affinity and predict DAOA expression in the substantia nigra and temporal cortex. This evidence concerns the gene TCF4 and mood disorder.