Family, twin and adoption studies have consistently indicated moderate-to-strong genetic contributions to the risk of major mood disorders.1 Genetic association and genome-wide association studies (GWAS) suggest that there is some degree of overlap for some specific disorders but also specific genetic diversity.2DAOA (D-amino acid oxidase activator), a gene located on human chromosome 13q33.2, plays a crucial role in the central nervous system through binding with DAO (encoding D-amino acid oxidase). The gene discussed is DAOA; the disease is mood disorder.