Additionally, a clinical trial (NCT03399448) sponsored by University of Pennsylvania is evaluating the antitumor efficacy of NY-ESO-1-specific TCR-T cells with the elimination of PD-1 and endogenous TCR by the CRISPR/Cas9 gene-editing system for the treatment of MM, melanoma, and other tumors. This evidence concerns the gene CTAG1A and Miyoshi myopathy.