In prior clinical trials, HER2-specific vaccines have shown efficacy and sustained levels of T-cell HER2 immunity, generating from active immunity.159 Evidence from prior trials have shown promising results for examining the potential use of HER2 based vaccines, in the adjuvant chemotherapy to prevent the recurrence in high-risk breast cancer patients.160 In a small group of patients with stage IV breast cancer, a dendritic cell-based vaccine was also been tested. The gene discussed is ERBB2; the disease is breast cancer.