The treatment with trastuzumab could improve the possibility of achieving pCR.226 A small randomized trial conducted by the MD Anderson cancer group was perhaps the first study confirming the role of anti-HER2 therapies in the neoadjuvant scenario.223,231 Although only 42 cases were enrolled, the competition of trastuzumab to sequential paclitaxel chemotherapy of four cycles followed by FEC of four cycles regimens resulted in an outstanding high rate of 2.5 times (66.7%) of pCR, than chemotherapy-alone arm (25%), p = 0.02. Here, ERBB2 is linked to cancer.