ERBB2 and breast cancer: At present, two phase III trials of everolimus in anti-HER2 setting are: Breast cancer trials of oral everolimus-1166,167 (BOLERO-1) evaluating the combination of everolimus, trastuzumab, and paclitaxel as first-line therapy, and BOLERO-3168 is a randomized, double-blind, multicenter trial, which explored the efficacy of everolimus in combination with trastuzumab and vinorelbine or placebo control therapy for locally advanced or metastatic patients with prior taxane therapy.