As per the Anatolian Society of Medical Oncology review, lapatinib plus capecitabine was recommended for HER2-postive ABC patients with brain metastasis.120 A total of 203 patients with HER2-positive MBC, who had progressed after trastuzumab-containing chemotherapy, were retrospectively evaluated at 11 centers between September 2009 and May 2011. This evidence concerns the gene ERBB2 and aneurysmal bone cyst.