The current strategies for AD treatment based on the Aβ hypothesis are mainly divided into the following categories: β- and γ-secretase inhibitors, which are used to inhibit Aβ production; antiaggregation drugs (including metal chelators), which are used to inhibit Aβ aggregation; protease activity-regulating drugs, which are used to clear Aβ; and immunotherapy.92 We will discuss recent progress regarding immunotherapy and BACE1 inhibitors. The gene discussed is BACE1; the disease is Alzheimer disease.