SQSTM1 and early-onset autosomal dominant Alzheimer disease: Meanwhile, SQSTM1 is prone to form aggregates or sequestosomes.48 SQSTM1 is a common constituent of cytoplasmic aggregates in various diseases such as Alzheimer’s disease and hepatocellular carcinoma.49,50 Nevertheless, clinical trials are warranted to confirm the value of targeting SQSTM1 accumulation in these disorders.