SQSTM1 has tumor-promoting capacity in addition to its well-known pro-autophagy function by activating Nrf2, mTORC1, and NFκB signaling pathways.39,40 In line with this, we confirmed that knockdown of SQSTM1 expression further enhanced the inhibition of cell proliferation by CQ (data not shown). This evidence concerns the gene SQSTM1 and neoplasm.