Similarly, the number of microvessels marked by CD31 was also significantly reduced in tumours treated with SKLB325 (17.00 ± 1.41) compared with the two control groups (68.40 ± 2.14 and 68.60 ± 1.97, ***p < 0.001, Fig. 6f, g). This evidence concerns the gene PECAM1 and neoplasm.