JMJD6 and chronic hepatitis B virus infection: These reports showed a decrease in the expression of JMJD6 in T lymphocytes of patients who had chronic hepatitis B virus infection,42 and the proliferation of CD4+ T cells could be inhibited by reducing the expression of JMJD6 in normal peripheral blood mononuclear cells.42,43 For the expression of JMJD6 in immune cells and its role in RNA metabolism, replication of viral RNA may be necessary.44,45