In A459 and U87 cells, we found that expression of iron transport proteins transferrin receptor 1 and divalent metal transporter 1 increased slightly (less than 2-fold) following siramesine and lapatinib treatment whereas transferrin, ferritin, and FPN expression fail to significantly increase (Fig.  and ) suggesting that the mechanism of ferroptosis differs from breast cancer cells. This evidence concerns the gene TF and breast cancer.