In many studies, it has been observed that elevated ROS could activate the MAPK/ERK signaling pathway and enhance the proliferation, invasion, and metastasis of tumor cells [40, 41]; most melanoma patients carried BRAF gene mutations, which might activate the MAPK/ERK signaling pathway, further promoting tumor cell proliferation through regulating the downstream signals, and ultimately leading to tumorigenesis and even tumor progression [42]. Here, BRAF is linked to neoplasm.