CERS2 and cancer: In this study, the mechanism in which CERS2 knockdown exerts an antimigratory effect on UMUC1 bladder cancer cells is not established, but while many studies suggest CERS2 as a putative pan-cancer metastatic suppressor gene, there are studies that suggest a more protumourigenic role for CERS2, albeit to a lesser extent [12, 30].