The results of the current study demonstrated that serum GP73 levels were comparable to serum ALT and AST in assessing the moderate to severe liver necroinflammation (G ≥ 2) of chronic hepatitis C patients, but its power in diagnosing advanced fibrosis (F ≥ 3) and cirrhosis (F = 4) showed no advantage, as compared to APRI and especially FIB-4. This evidence concerns the gene GPT and chronic hepatitis C virus infection.