Furthermore, serum GP73 levels were found significantly increased in hepatic necroinflammation, fibrosis, and cirrhosis [21–25, 33–36] and deemed to be an effective and reliable serological surrogate for the diagnosis of advanced fibrosis and cirrhosis and for monitoring the progression of the liver injury and diseases [21–23, 25]. The gene discussed is GOLM1; the disease is Cirrhosis.