HMGB1 and neoplasm: Generally, three major signal cues have been released when host cells experience ICD, including cell surface exposure of calreticulin (CRT) which stimulates phagocytosis of dendritic cells (DCs), ATP release which recruits DC cells, and secretion of High Mobility Group Box 1 (HMGB1) which promotes complexation of DC cells with moribund tumor cells and induces T cells-based specific tumor immunity [10].