CASP3 and leukemia: In studies on leukemia cells, it was found that 15,16-dihydrotanshinone I increased the phosphorylation of JNK and the expression of Fas L, which may be the reason for the upregulation of Bad and Bax expressions as well as the activation of caspase 3/8/9, leading to the apoptosis of leukemia cells [79].