Trilayered nanocomposite hydrogel scaffolding, composed of chitin poly(lactic-co-glycolic) acid (PLGA)/nanobioactive glass ceramic (nBGC)/cementum protein 1 (CEMP1), chitin-PLGA/fibroblast growth factor 2 (FGF2), and chitin-PLGA/nBGC/platelet-rich plasma- (PRP-) derived growth factors acting as the cementum layer, PDL layer, and alveolar bone layer, respectively, achieved a complete healing with the formation of new cementum, fibrous PDL, and alveolar bone with well-defined trabeculae, which served as a good alternative regenerative approach for periodontal diseases [150]. The gene discussed is FGF2; the disease is periodontal disorder.