Cleidocranial dysplasia (CCD) patients are characterized by delayed tooth eruption due to runt-related transcription factor 2 (Runx2) mutation, DFCs-CCD patients displayed significantly lower osteogenic, osteoclast-inductive and matrix-degrading capacities, mechanistically contacted with disturbed RANK/RANKL/OPG signaling and decreased expression of matrix metalloproteinase 9 (MMP9) and MMP2 [56–58]. This evidence concerns the gene MMP9 and cleidocranial dysplasia 1.