SOX2 and osteoarthritis: In another study of fast- and slow-growing subsets of hBM-MSCs from osteoarthritis patients, genes encoding sex-determining region Y-box 2 (SOX2), notch homolog 1 (NOTCH1), and the notch ligand delta-like 3 (DLL3) were among the upregulated genes in fast-growing MSCs [56].