Previous studies have shown that the LIN28B-RAN-AURKA axis was involved in the development of neuroblastoma, and AURKA, as a confluence of LIN28B-RAN signaling, could further promote cell cycle progression by phosphorylating many cell cycle regulators and stabilizing N-myc protein (encoded by MYCN gene) [41, 42]. This evidence concerns the gene AURKA and neuroblastoma.