More recently, it was demonstrated that both CD133 mRNA and protein expression are important biomarkers for prognosis as they positively correlate with higher tumor grade, occurrence of lymph node metastasis, negative PR and ER and positive HER2 status, advanced TNM stage, and poor overall survival (OS) [23–25]. Here, PROM1 is linked to metastatic malignant neoplasm in the lymph nodes.