PROM1 and breast carcinoma: The CD133-related proteins included the actin-binding protein tropomyosin4 (Tm4), upregulated in highly metastatic breast cancer cell lines and associated with lymph node metastasis of breast tumors [41] and AdoHcyase (Figure 2), known to play a key role in the control of DNA methylation [42] and in the regulation of cell cycle, apoptosis, and cellular differentiation of breast tumor cells [43].