Low ANLN and high KDR gene expression is associated with a favorable clinical outcome, and low ANLN is naturally accompanied by decreased KDR in malignant tumor cells (Figure 3); by externally upregulating KDR and downregulating ANLN in triple negative cells MDAMB231, we established a cell line sharing similar phenotypical features with luminal breast cancer cells. The gene discussed is ANLN; the disease is cancer.