Moreover, hypoxia-mediated upregulation of CD73 and of ADO generation also influences metabolic adaptation of the T lymphocytes surrounding the tumor, inducing a switch toward glycolysis, with robust upregulation of glucose and lactate transporters and of lactate dehydrogenase (LDHA) and pyruvate kinase 2 (PKM2). The gene discussed is NT5E; the disease is neoplasm.