Our results showed that level of RORα increased by administration of pcDNA–RORα (Figures 4B,C) and RORα overexpression in arthritis mice reduced the arthritis score and the incidence of arthritis compared to those in mice receiving control pcDNA vector from the early phase of the disease until 90 days after arthritis induction (Figure 4A). The gene discussed is RORA; the disease is Arthritis.