The main mechanisms by which NK cells can recognize and eliminate virus-infected cells involve the employ of (i) activating receptors for cellular ligands often overexpressed upon infection, (ii) activating receptors for virus-derived ligands, (iii) activating receptors, i.e., NKG2C and aKIRs, recognizing virus-modified HLA-I molecules, and (iv) CD16-mediated antibody-dependent cellular cytotoxicity (ADCC) (Hammer et al., 2018b). Here, KLRC2 is linked to infection.