FCGR3A and viral infectious disease: Another major mechanism employed by NK cells in controlling both primary viral infections, when adaptive immunity is already established, and secondary reactivations (either subclinical or clinical), relies on the activating receptor CD16 (FcγRIIIa), the low-affinity receptor for the immunoglobulin Fc fragment (Braud et al., 1998; Vivier et al., 2011).