Although the generation of this subset seems to be promoted exclusively by CMV, its increased ability to eliminate Ab-coated infected cells through enhanced ADCC could keep under control infections and reactivations caused by other viruses, as suggested by studies reporting efficient ADCC-mediated killing of opsonized EBV- and HSV-infected targets by adaptive NKG2C+ NK cells (Costa-Garcia et al., 2015; Moraru et al., 2015). Here, KLRC2 is linked to infection.