Sequencing analysis of the promoter and 5′-UTR regions of the MKRN3 gene in the cohort of 73 index girls with CPP revealed three novel heterozygous mutations (−166, −865, −886 nt upstream to the TSS) located in the proximal promoter region and one novel heterozygous mutation located in the 5′-UTR (+13 nt downstream to the TSS) region (Figure 1). The gene discussed is MKRN3; the disease is central precocious puberty.