RYR2 and heart disorder: Posttranslational modifications of the channel, including phosphorylation by PKA and/or CaMKII and oxidation of reactive cysteines, have been implicated in the RyR2 hyperactivity characteristic of cardiac disease and aging (Belevych et al., 2012; Zima et al., 2014; Hamilton and Terentyev, 2018, 2019).