Although further studies are warranted to evaluate the mechanisms by which amurensin H mediates Syk/NF-κB in COPD disease, some of the limitations of this study are addressed in that i) LPS/CS-induced mice only have relevance to inflammation found in COPD; long-term COPD models are needed to test the anti-inflammatory effect of amurensin H and potential mechanisms; ii) the effect of amurensin H on Syk transcription in vitro was not determined. This evidence concerns the gene SYK and chronic obstructive pulmonary disease.