TARDBP and amyotrophic lateral sclerosis: For example, AD is characterized by the aggregation of beta-amyloid protein and microtubule-associated protein Tau; PD by the accumulation of neuronal terminal protein alpha-synuclein; ALS by the accumulation of phosphorylated TDP43 (a transcription inhibitor) and superoxide dismutase 1 (SOD1), and Huntington’s disease by the accumulation of mutant Huntington’s protein (mHTT; Luarte et al., 2016).