TARDBP and amyotrophic lateral sclerosis: ALS is a serious neurological disease in which the cortex, brainstem, and spinal motor neurons are affected by prion-like misfolded proteins, e.g., superoxide dismutase-1 (SOD1) and TDP-43, resulting in neurodegeneration and is disease marked by protein dysfunction without RNA or DNA components (Lee et al., 2016; Maguire, 2017).