SOD1 and amyotrophic lateral sclerosis: Data show that about 5–10% of ALS patients are familial and we can observe important mutations in the SOD1, FUS, TARDBP, C9ORF72, and bone morphogenetic protein modifier genes, all of which increase the susceptibility for ALS, but it has been made clear that the SOD1 mutation is the main genetic factor of ALS (Bonafede et al., 2016; Sohrab et al., 2018).