To explore the function of SUV39H2 in glioma cells, SUV39H2 was knocked down in U251 and U87 cell lines by the lentiviral system with 2 shRNA sequences targeting SUV39H2 (SUV39H2-sh1 and SUV39H2-sh2) or a scrambled sequence as a control (CTRL). This evidence concerns the gene SUV39H2 and central nervous system cancer.