Taken together, these findings uncovered critical tumor suppressive roles of HNF1B, acting together with RBBP7 to suppress EMT process by inhibiting SLUG expression, and that this pathway is subjected to a negative regulation of EZH2 in prostate cancer cell lines, PC-3 and DU145, and likely in prostate cancer as well. Here, RBBP7 is linked to prostate carcinoma.