Here in this study, we find that the tumor suppressor HNF1B is repressed by EZH2 in prostate cancer cell lines, and functions together with RBBP7 in suppressing EMT through down-regulation of SLUG expression (Fig. 4g), which expands our knowledge of how EZH2 is involved in this deleterious disease. This evidence concerns the gene RBBP7 and prostate cancer.