Our novel data suggest that the IL6/ STAT3 signaling pathway enhances the effect of NFs on ccRCC cell metastasis, while GATA3 binds to the −1710~−1530 region of STAT3 promoter and inhibits the IL6-induced STAT3 activation by repressing its transcription. This evidence concerns the gene GATA3 and nonpapillary renal cell carcinoma.