To further elucidate the role of the IL6/STAT3 pathway in the NF-promoted ccRCC cell migration, we added 200 μg/ml of human recombinant IL6 to normal medium cultured 769-P and ACHN cells, or 50 μg/ml of IL6 neutralizing antibody (anti-IL6 antibody) to NF-CM cultured 769-P and ACHN cells, and the performed transwell assay to evaluate ccRCC cells migration. The gene discussed is STAT3; the disease is nonpapillary renal cell carcinoma.