ERLIN2 and hereditary spastic paraplegia: Mutations in ERLIN1 and ERLIN2 cause Hereditary Spastic Paraplegia (HSP)13–20, a heterogeneous group of neurodegenerative motor neuron disorders (MND), primarily affecting the long motor axons of the corticospinal tract motor neurons and leading to the cardinal symptoms of progressive lower limb spasticity and weakness21.