Combination of Gemcitabine with Digoxin resulted in extremely reduced tumors that were mainly composed of macrophages and giant multinucleated immune cells surrounding a few SABG and p21 positive, non-proliferating CK AE1/AE3 positive tumor cells (Fig. 4d and Supplementary Fig. 4b). The gene discussed is SLC4A1; the disease is neoplasm.