In lung cancer, to specifically deliver an anti-nucleolin (NCL) aptamer to lung cancer cells, a chimera composed of two NCL-AsiCs linked together by a hetero-bifunctional crosslinker (sulfo-SMPB) was generated to specifically block snail family zinc finger 2- (SLUG) and neurophilin 1- (NRP1) driven metastatic pathways and epithelial-mesenchymal transition [34]. The gene discussed is NRP1; the disease is lung carcinoma.