In lung cancer, to specifically deliver an anti-nucleolin (NCL) aptamer to lung cancer cells, a chimera composed of two NCL-AsiCs linked together by a hetero-bifunctional crosslinker (sulfo-SMPB) was generated to specifically block snail family zinc finger 2- (SLUG) and neurophilin 1- (NRP1) driven metastatic pathways and epithelial-mesenchymal transition [34]. Here, NRP1 is linked to lung cancer.