In the second study, Kang et al. described a male fetal monkey in which CRISPR/Cas9 genome editing had produced Nr0b1-null mutations in most somatic tissues and in the gonads, successfully recapitulating human adrenal hypoplasia congenita and hypogonadotropic hypogonadism (AHC-HH) (Kang et al., 2015). The gene discussed is NR0B1; the disease is alternating hemiplegia of childhood.