TMBIM6 and subarachnoid hemorrhage: Recently, limited studies of in vivo models of ischemia-reperfusion, traumatic brain injury (Krajewska et al., 2011) and subarachnoid hemorrhage (Liu et al., 2018; Shi et al., 2018), either using transgenic mice that overexpress BI-1 or a lentiviral vector to introduce the gene, have shown BI-1 to confer protection by interfering with apoptotic signals and blood–brain barrier (BBB) disruption (Krajewska et al., 2011; Chae et al., 2004; Shi et al., 2018; Liu et al., 2018).