CCK and Anxiety: One proposal is that endocannabinoids could inhibit CCK release in the BA (Beinfeld and Connolly, 2001; Chhatwal et al., 2009) and thereby oppose the peptide’s pro-fear/anxiety effects to enable extinction (Frankland et al., 1997; Harro, 2006; Del Boca et al., 2012; Bowers and Ressler, 2015).