The contribution of RUNX1 towards angiogenesis in steatosis may also be deduced by the fact that many of its target genes, including eNOS and PI3KCA, are known to be involved in various aspects of angiogenesis, including EC proliferation, sprouting and vascular stabilization during hepatic steatosis and inflammation in high fat diet mice [30,31]. This evidence concerns the gene NOS3 and steatosis.