WES performed on both subjects, identified, in Fam3-01, three rare variants of known risk for AMD (and HUS): ABCA4 p.G1961E (rs1800553) [29]; C3 p.R735W (rs117793540) [30]; and CFI p.K441R (rs41278047) [31,32] (Figure 2R–T). Here, C3 is linked to age-related macular degeneration.