C3 and age-related macular degeneration: Among the six rare variants identified in the current study, four have previously been described in association with AMD in other populations (ABCA4 p.G1961E, CFI p.K441R, C3 p.R735W, and CFH p.R1210C), and one variant has been reported in Tunisian Jews (CFI p.V412M) [18]; and the PLEKHA1 p.S177N variant has been reported in only two cases of familial AMD [32,35].