BRAF and melanoma: Notably, an over-representation enrichment analysis carried out using the GEne SeT AnaLysis Toolkit (WebGestalt, http://webgestalt.org) revealed that the most relevant over-represented pathways (p < 0.01) defined by the list of differently expressed genes in 1-treated vs. untreated A375 cells with a fold-change >|2.0| comprised terms such as signaling by BRAF and RAF fusions, oncogenic MAPK signaling, and signal attenuation (Supporting Information Table S4), which are all relevant, targetable pathways in BRAF-mutant melanoma cells [3].