Genetic alterations of KIT in melanoma include somatic gain-of-function mutations and copy number increases of wild-type KIT [7], whereas mutant receptors were found only in 2% of all cutaneous melanomas, thus representing a rare event for targeted treatment, and in up to 20% of mucosal, acral, and chronic sun-damaged skin melanomas [8]. The gene discussed is KIT; the disease is cutaneous melanoma.