On the other hand, PCa patients harboring BRCA1/2 mutations could possibly benefit to a greater degree from combination of apalutamide and EBRT compared to BRCA1/2 wild-type patients, as intrinsic HR repair defects in these patients plus compromised NHEJ repair by apalutamide would render the tumor cells exquisitely vulnerable to IR. Here, BRCA1 is linked to posterior cortical atrophy.