The recurrent alterations of FLT3 (43%), WT1 (14%), NRAS (10%) and KRAS (4%) in newly diagnosed APL were reported, whereas mutations in other genes commonly mutated in myeloid leukemia including DNMT3A, NPM1, TET2, ASXL1 and IDH1/2 were absent [44]. This evidence concerns the gene FLT3 and acute promyelocytic leukemia.