Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) which is characterized by a reciprocal and balanced translocation involving the retinoic acid receptor α (RARa) on chromosome 17 and promyelocytic leukemia (PML) gene on chromosome 15, and generates the oncogenic PML-RARα fusion protein [1,2,3]. The gene discussed is PML; the disease is leukemia.