The first study to propose a molecular risk score in APL was reported by Hecht et al. Although the sample size was limited (79 patients), Hecht et al. demonstrated that BAALC, ERG and WT1 expression levels integrated into a score that could offer a promising approach to guide the monitoring of patients with APL treated with ATRA and high doses of cytarabine [55,56]. Here, ERG is linked to acute promyelocytic leukemia.