Clinical significance of ATM, PTEN, p85α, and XIAP expression in human ovarian cancers: Similar to the data shown for LN18 cells, ATM depletion in p85α deficient OVCAR3 cells was associated with reduced migration (Figure 6D,E) and invasion (Figure 6F) compared to p85α proficient OVCAR4 cells. The gene discussed is XIAP; the disease is ovarian cancer.