The rationale for testing the effect of HGF stimulation was that our previous studies on the SCLC cells established the multipurpose nature of MET/HGF pathway activation during tumor progression and invasion, which occurs via dysregulation of diverse biological functions, such as proliferation and differentiation, transcriptional control, cell-cycle G1/S checkpoint, cytoskeletal functions, survival, motility, and apoptosis [20]. This evidence concerns the gene HGF and neoplasm.