Chen et al. have recently found that LIPUS treatment mitigates LPS-induced memory impairment, repression of inflammation as well as BDNF decline in an Alzheimer’s disease animal model via the modulation of TLR4/NF-κB signaling and CREB/BDNF expression [19]. The gene discussed is BDNF; the disease is early-onset autosomal dominant Alzheimer disease.