Moreover, the increased Bax protein expression and decreased Bcl-2 protein expression were observed in the left cerebral hemisphere tissues of recurrent stroke mice, which could be effectively reversed by LIPUS treatment (Figure 3C; Bcl-2: Recurrent-MCAO, 0.90 ± 0.03, Recurrent-MCAO+LIPUS, 1.69 ± 0.15 (fold of control), n = 6, p < 0.05; Bax: Recurrent-MCAO, 2.24 ± 0.18, Recurrent-MCAO+LIPUS, 1.68 ± 0.13 (fold of control), n = 6, p < 0.05). This evidence concerns the gene BAX and stroke disorder.