DDB2 also represses head and neck squamous cell carcinoma and colon cancer progression by recruiting the histone H3K9 methylase suv39h (suppressor of variegation 3-9 homolog 1) to limit the transcriptional activity of Snail and ZEB1 (Zinc finger E-box Binding homeobox 1) factors and their epithelial-to-mesenchymal functions [25]. This evidence concerns the gene ZEB1 and colonic neoplasm.