BCL2 and ovarian carcinoma: Besides, DDB2 participates in sensitizing ovarian cancer cells to cisplatin-mediated apoptosis through the downregulation of the bcl-2 (B-cell lymphoma 2) transcriptional machinery in a HDAC1-dependent (Histone deacetylase 1) manner and the ubiquitylation of the antiapoptotic protein bcl-2 [34].