In a second dataset comprising 75 HCC patients (Wurmbach Liver [22]), HDAC 1 and 2, HDAC 4 and 5 and HDAC11 were significantly upregulated, whereas HDAC 3, 8, 9, 6 and 10 were not altered compared to non-neoplastic liver tissue (Figure 2B). This evidence concerns the gene HDAC11 and hepatocellular carcinoma.