To further establish the pathophysiological relevance of the Cav-1–P2Y2R interaction, we determined if caveolin-1 expression in 1321N1 astrocytoma cells impacted the P2Y2R signaling responses (ERK 1/2 and Akt) after mechanical injury. The gene discussed is P2RY2; the disease is astrocytoma (excluding glioblastoma).