Those tumors do not harbor alterations seen in other brain tumors such as methylation of the promoter of O6-methylguanine-DNA methyltransferase (MGMT), co-deletion of 1p/19q, or mutations of isocitrate dehydrogenase enzyme isoform 1 (IDH1), IDH2, alpha-internexin, or Tp53 [30]. Here, MGMT is linked to brain neoplasm.